CovidFranceV1, Main, Exploration, bibRecord, 000905

Predictive factors of mortality in patients treated with tocilizumab for acute respiratory distress syndrome related to coronavirus disease 2019 (COVID-19).

Identifieur interne : 000905 ( Main/Exploration ); précédent : 000904; suivant : 000906

Predictive factors of mortality in patients treated with tocilizumab for acute respiratory distress syndrome related to coronavirus disease 2019 (COVID-19).

Auteurs : Anne Lohse [France] ; Timothée Klopfenstein [France] ; Jean-Charles Balblanc [France] ; Pierre-Yves Royer [France] ; Marie Bossert [France] ; Vincent Gendrin [France] ; Aline Charpentier [France] ; Ana-Maria Bozgan [France] ; Julio Badie [France] ; Charlotte Bourgoin [France] ; Remy Contreras [France] ; Isabelle Mazurier [France] ; Thierry Conrozier [France] ; Souheil Zayet [France]

Source :

Microbes and infection [ 1769-714X ] ; 2020.

RBID : pubmed:32574789

Abstract

COVID-19 patients (n = 34) suffering from ARDS were treated with tocilizumab (TCZ). Outcome was classified in two groups: "Death" and "Recovery". Predictive factors of mortality were studied. Mean age was 75.3, mean oxygen (O₂) requirements 10.4 l/min. At baseline, all patients had multiple biological abnormalities (lymphopenia, increased CRP, ferritin, fibrinogen, D-dimer and liver enzymes). 24 patients (70.5%) recovered after TCZ therapy and 10 died (29.5%). Deceased subjects differed from patients in whom treatment was effective with regard to more pronounced lymphopenia (0.6 vs 1.0 G/l; p = 0.037), lower platelet number (156 vs 314 G/l; p = 0.0001), lower fibrinogen serum level (0.6 vs 1.0 G/l; p = 0.03), higher aspartate-amino-transferase (108 vs 57 UI/l; p = 0.05) and greater O₂ requirements (11 vs 8 l/min; p = 0.003).

DOI: 10.1016/j.micinf.2020.06.005
PubMed: 32574789
PubMed Central: PMC7305501

Affiliations:

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<author><name sortKey="Charpentier, Aline" sort="Charpentier, Aline" uniqKey="Charpentier A" first="Aline" last="Charpentier">Aline Charpentier</name>
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<author><name sortKey="Bourgoin, Charlotte" sort="Bourgoin, Charlotte" uniqKey="Bourgoin C" first="Charlotte" last="Bourgoin">Charlotte Bourgoin</name>
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<author><name sortKey="Contreras, Remy" sort="Contreras, Remy" uniqKey="Contreras R" first="Remy" last="Contreras">Remy Contreras</name>
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<author><name sortKey="Conrozier, Thierry" sort="Conrozier, Thierry" uniqKey="Conrozier T" first="Thierry" last="Conrozier">Thierry Conrozier</name>
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<series><title level="j">Microbes and infection</title>
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<front><div type="abstract" xml:lang="en">COVID-19 patients (n = 34) suffering from ARDS were treated with tocilizumab (TCZ). Outcome was classified in two groups: "Death" and "Recovery". Predictive factors of mortality were studied. Mean age was 75.3, mean oxygen (O<sub>2</sub>
) requirements 10.4 l/min. At baseline, all patients had multiple biological abnormalities (lymphopenia, increased CRP, ferritin, fibrinogen, D-dimer and liver enzymes). 24 patients (70.5%) recovered after TCZ therapy and 10 died (29.5%). Deceased subjects differed from patients in whom treatment was effective with regard to more pronounced lymphopenia (0.6 vs 1.0 G/l; p = 0.037), lower platelet number (156 vs 314 G/l; p = 0.0001), lower fibrinogen serum level (0.6 vs 1.0 G/l; p = 0.03), higher aspartate-amino-transferase (108 vs 57 UI/l; p = 0.05) and greater O<sub>2</sub>
 requirements (11 vs 8 l/min; p = 0.003).</div>
</front>
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<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>09</Day>
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<Title>Microbes and infection</Title>
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<ArticleTitle>Predictive factors of mortality in patients treated with tocilizumab for acute respiratory distress syndrome related to coronavirus disease 2019 (COVID-19).</ArticleTitle>
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<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.micinf.2020.06.005</ELocationID>
<Abstract><AbstractText>COVID-19 patients (n = 34) suffering from ARDS were treated with tocilizumab (TCZ). Outcome was classified in two groups: "Death" and "Recovery". Predictive factors of mortality were studied. Mean age was 75.3, mean oxygen (O<sub>2</sub>
) requirements 10.4 l/min. At baseline, all patients had multiple biological abnormalities (lymphopenia, increased CRP, ferritin, fibrinogen, D-dimer and liver enzymes). 24 patients (70.5%) recovered after TCZ therapy and 10 died (29.5%). Deceased subjects differed from patients in whom treatment was effective with regard to more pronounced lymphopenia (0.6 vs 1.0 G/l; p = 0.037), lower platelet number (156 vs 314 G/l; p = 0.0001), lower fibrinogen serum level (0.6 vs 1.0 G/l; p = 0.03), higher aspartate-amino-transferase (108 vs 57 UI/l; p = 0.05) and greater O<sub>2</sub>
 requirements (11 vs 8 l/min; p = 0.003).</AbstractText>
<CopyrightInformation>Copyright © 2020 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lohse</LastName>
<ForeName>Anne</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Rheumatology, Nord Franche-Comté Hospital, Belfort, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Klopfenstein</LastName>
<ForeName>Timothée</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, Nord Franche-Comté Hospital, Belfort, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Balblanc</LastName>
<ForeName>Jean-Charles</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>Department of Rheumatology, Nord Franche-Comté Hospital, Belfort, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Royer</LastName>
<ForeName>Pierre-Yves</ForeName>
<Initials>PY</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, Nord Franche-Comté Hospital, Belfort, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bossert</LastName>
<ForeName>Marie</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Rheumatology, Nord Franche-Comté Hospital, Belfort, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gendrin</LastName>
<ForeName>Vincent</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, Nord Franche-Comté Hospital, Belfort, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Charpentier</LastName>
<ForeName>Aline</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Rheumatology, Nord Franche-Comté Hospital, Belfort, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bozgan</LastName>
<ForeName>Ana-Maria</ForeName>
<Initials>AM</Initials>
<AffiliationInfo><Affiliation>Department of Rheumatology, Nord Franche-Comté Hospital, Belfort, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Badie</LastName>
<ForeName>Julio</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Intensive Care Unit, Nord Franche-Comté Hospital, Belfort, France; Clinical Research Unit, Nord Franche-Comté Hospital, Belfort, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bourgoin</LastName>
<ForeName>Charlotte</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Clinical Research Unit, Nord Franche-Comté Hospital, Belfort, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Contreras</LastName>
<ForeName>Remy</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacology, Nord Franche-Comté Hospital, Belfort, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mazurier</LastName>
<ForeName>Isabelle</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Department of Biology, Nord Franche-Comté Hospital, Belfort, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Conrozier</LastName>
<ForeName>Thierry</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Rheumatology, Nord Franche-Comté Hospital, Belfort, France; Clinical Research Unit, Nord Franche-Comté Hospital, Belfort, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zayet</LastName>
<ForeName>Souheil</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, Nord Franche-Comté Hospital, Belfort, France. Electronic address: souhail.zayet@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>06</Month>
<Day>20</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>France</Country>
<MedlineTA>Microbes Infect</MedlineTA>
<NlmUniqueID>100883508</NlmUniqueID>
<ISSNLinking>1286-4579</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Acute respiratory distress syndrome</Keyword>
<Keyword MajorTopicYN="N">Biomarkers</Keyword>
<Keyword MajorTopicYN="N">COVID-19</Keyword>
<Keyword MajorTopicYN="N">Predictive factors</Keyword>
<Keyword MajorTopicYN="N">SARS-CoV-2</Keyword>
<Keyword MajorTopicYN="N">Tocilizumab</Keyword>
</KeywordList>
<CoiStatement>Declaration of Competing Interest The authors declare that they have no conflict interests.</CoiStatement>
</MedlineCitation>
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<Month>06</Month>
<Day>18</Day>
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<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>06</Month>
<Day>18</Day>
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Predictive factors of mortality in patients treated with tocilizumab for acute respiratory distress syndrome related to coronavirus disease 2019 (COVID-19).

Predictive factors of mortality in patients treated with tocilizumab for acute respiratory distress syndrome related to coronavirus disease 2019 (COVID-19).

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